http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107011252-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2017-06-09^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-06-08^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-06-08^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-107011252-B |
| titleOfInvention | The method for drawing azole intermediate and drug is prepared using the green technology for substituting the poisonous and harmful substances such as phosgene, thionyl chloride |
| abstract | A kind of method that the green technology preparation high-purity drawing azole intermediate of the poisonous and harmful substances such as phosgene, thionyl chloride is substituted the invention discloses application.The preparation method is：By Ph 3 PO is dissolved in organic solvent and is placed in reaction bulb, and BTC is added dropwise, forms efficient chlorinating agent, rear insulation reaction is added dropwise for a period of time, azoles hydroxylate will be drawn to be dissolved in after organic solvent the system that is added drop-wise to again, insulation reaction for a period of time after, filter dry be made and draw azoles chloride.Ph in the process 3 PO equivalents regenerate, and Ph is precipitated under low temperature after mother liquor fraction concentration 3 PO, Ph 3 PO is applied mechanically through the washing of small polar solvent is repeatable.The advantages that present invention has side reaction few, and product quality is high, and " three wastes " pollution is few, and Atom economy is high, has preferable popularizing application prospect.The present invention also provides the drawing azoles chlorides being prepared by green technology further to obtain relevant drawing azole drug, and the drug is apparent higher than the pharmaceutical purity obtained by conventional method. |
| priorityDate | 2017-06-09^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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