| abstract |
A 3,4,5-trisubstituted-4,5-dihydroisoxazole and its derivatives as well as their synthesis method and application. The present invention mainly relates to a method for synthesizing isoxazoline compounds. No catalyst is needed for the synthesis. Aldehydes and oxime esters are converted into isoxazolines and their compounds only under the action of alkali and organic solvents are used as solvents. The technical scheme of derivatives; it overcomes the complex synthetic steps in the existing synthetic methods of isoxazoline compounds, which requires multi-step synthetic processes to complete, and also requires the use of metal catalysts, chemically equivalent metal oxidants or peroxides Difficulty; it maintains atom economy to the greatest extent; it has stable molecular structure, excellent chemical properties, molecular dicing and compound fragments contain rich biological and pharmacological activities; it also has simple reaction system, mild reaction conditions, Fewer reaction equipment, simple experimental operation, wide sources of materials, high yield, easy expansion of users and applications, high product utilization value, predictable market commercialization prospects, etc. |