| abstract |
The invention provides a compound represented by a formula (I) or a pharmaceutically acceptable salt or prodrug thereof. The compound has novel structure, high efficiency, low toxicity and excellent CXCR4 antagonistic activityCan block HIV invasion to infect human target cells or treat or prevent AIDS or mobilize human bone marrow hematopoietic cells, mesenchymal stem cells and stem cells or interfere with CXCL12/CXCR4 mediated cell migration and adhesion or prevent, treat CXCR4 mediated tumor metastasis, invasion and growth or block CXCL12/CXCR4 mediated autoimmune and inflammatory reactions; the compound can be used as an effective component in a pharmaceutical composition to be used together with other anti-HIV drugs for preventing and treating HIV or be used together with other drugs for treating or preventing leukemia, lymphoma, myeloma and solid tumor for preventing and treating tumor. |