| abstract |
The present disclosure relates to compositions and methods useful for producing heterologous proteins in filamentous fungal cells, particularly filamentous fungal cells comprising three endogenous proteases with reduced activity and recombinant polynucleotides encoding heterologous polypeptides , wherein the polypeptide is produced at a level at least two-fold higher than the level of production of the polypeptide in a corresponding parental filamentous fungal cell in which the protease does not have reduced activity. |