http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108261413-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6c0e8d16adfed30a2231ba4b252c19aa |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4174 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4174 |
| filingDate | 2016-12-31^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae1225ed4c50e304212c5baee09ab18a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5112eb0f4a33d27df3cd83b954c859ea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dac0cb5ae8ddae1a1ef564caaff82fa5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d4926810a62b6d0c873aa4b494b79143 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b51cd5fe1ad5274ca507f3959eebcfcb |
| publicationDate | 2018-07-10^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108261413-A |
| titleOfInvention | Application of IMB-301 in the preparation of antiviral drugs |
| abstract | The present invention relates to the application of compound IMB-301 in the preparation of antiviral drugs with hA3G as the target. Disclosed is an antiviral active compound targeting hA3G, which is obtained through virtual screening. The biological activity shows that IMB-301 can specifically inhibit Vif from degrading hA3G by inhibiting the binding of Vif to hA3G; and IMB-301 up-regulates the intracellular The level of hA3G effectively inhibits the replication of viruses (such as HIV), that is, IMB‑301 inhibits the virus depends on hA3G. The active compound in the present invention selects hA3G as the target, which solves the problem of drug resistance caused by high virus mutation, and has no cross-resistance with currently clinically used antiviral drugs. |
| priorityDate | 2016-12-31^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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