http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108467360-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-80 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-82 |
| filingDate | 2018-06-22^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-04-30^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-04-30^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108467360-B |
| titleOfInvention | Preparation method and intermediate of apatinib |
| abstract | The invention discloses a preparation method of apatinib and an intermediate thereof, wherein the preparation method comprises the following steps: amidating the intermediate 2- [ (pyridine-4-methyl) amino ] nicotinic acid alkane ester and 1- (4-aminophenyl) -1-cyanocyclopentane in the presence of alkaline matter in a reaction solvent to produce apatinib; the method of the invention can make the reaction process milder, has simple operation and no pollutant generation, and can obtain more ideal yield and purity. |
| priorityDate | 2018-06-22^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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