| abstract |
The present disclosure describes thiazole and picolinamide derivatives of formula (I), or pharmaceutically acceptable salts thereof, compositions and methods of use, wherein: X is C or N; A, B, and D are rings; the bond - represents a normalized bond in an aromatic ring containing both N and X, which is formally represented by a C=C bond when X is C and a single bond when X is N; ring A has the formula (A-1) or (A-2); wherein E1 and E2 are rings. The compounds inhibit the activity of Pim kinase and are therefore useful in the treatment of diseases associated with Pim kinase activity, including, for example, cancer and other diseases. |