http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109253990-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K2211-1491 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08B37-0072 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6428 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K11-025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09K11-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09K11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64 |
| filingDate | 2018-03-28^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-10-15^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-10-15^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109253990-B |
| titleOfInvention | Nano fluorescent probe for targeting pancreatic cancer circulating tumor cells |
| abstract | The invention provides a nano fluorescent probe for targeting pancreatic cancer circulating tumor cells, which comprises H 2 O 2 Responsive fluorescent small molecules and polymers targeting pancreatic cancer surface markers, said H 2 O 2 The responsive fluorescent small molecule and the polymer targeting the pancreatic cancer surface marker have opposite hydrophilicity and hydrophobicity. According to the invention, through the specific combination of hyaluronic acid and CD44 antigen with high expression on the surface of pancreatic cancer tumor, the HA-NP-BE nano fluorescent probe can enter pancreatic cancer cells in a targeted manner to detect H in the cells 2 O 2 The imaging is carried out, and the kit has quick response, can effectively distinguish pancreatic cancer tumor cells from normal cells, detects CTC in pancreatic cancer tumor patients, and is helpful for early diagnosis of pancreatic cancer. |
| priorityDate | 2017-07-12^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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