| abstract |
The present invention discloses peptoids and related compounds, including peptoid affinity ligands and hybrid peptoids for binding and/or purifying immunoglobulins, immunoglobulin fragments or immunoglobulin fusion proteins thereof. Also disclosed are methods of making peptoid affinity ligands and using them to bind, purify and/or isolate immunoglobulins and related compounds. Such peptoid affinity ligands include peptoid compounds consisting of sequentially linked peptoid residues forming a peptoid backbone to which one or more nitrogens are attached to the peptoid residues Functional groups configured to provide the desired binding affinity. A peptoid may also include a peptoid backbone having at least one functional group attached to the alpha carbon (C) of a peptide bond in the peptoid backbone, thereby forming a hybrid peptoid. |