http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109369467-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C277-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-215 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C279-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-48 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C279-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C277-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-215 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-12 |
| filingDate | 2018-11-21^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-05-28^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-05-28^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109369467-B |
| titleOfInvention | N2-polyfluoroalkyl acylguanidines and process for their preparation |
| abstract | The invention relates to a method for producing N 2 -polyfluoroalkyl acylguanidines and a process for their preparation. Said N 2 The polyfluoroalkyl acylguanidine compound has a structure shown in a general formula (I) or (II). The synthesis method of the compound comprises the following steps: placing guanidine compounds or urea compounds or imidazoline compounds into a reaction bottle, adding an organic solvent and polyfluoroalkyl halide, stirring for 6-15 hours at room temperature under illumination, and monitoring the reaction end point by TLC; pouring the obtained product into water, extracting with dichloromethane, collecting an organic phase, drying, and distilling under reduced pressure to remove the solvent; separating and purifying the obtained crude product by a silica gel column chromatography method to obtain N 2 -polyfluoroalkylacylguanidine products. The synthetic route of the invention has the advantages of simple method, low cost, wide range, mild condition, safe reaction route, simple and convenient operation, and the like. The compound can be used as potential histamine H 2 Receptor agonists are used. Or |
| priorityDate | 2018-11-21^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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