http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109476670-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-551 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4196 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 |
| filingDate | 2017-10-02^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-06-28^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-06-28^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109476670-B |
| titleOfInvention | Bicyclic heteroaryl derivatives |
| abstract | The invention relates to compounds of formula (I), wherein R 1 Is hydrogen, lower alkyl substituted by halogen, lower alkoxy or lower alkoxy substituted by halogen; and R if n is 2 or 3 1 May be different; r 2 Is hydrogen, lower alkyl substituted by halogen, CN, lower alkoxy or lower alkoxy substituted by halogen; x is CH or N; m is 1, 2 or 3; - () m Is- (CH) 2 ) m -; n is 1, 2 or 3; ar is a five membered heteroaryl selected from (A), (B), (C), (D), (E) or (F), wherein R is 3 Is hydrogen, methyl or chlorine; r 4 Is hydrogen or methyl; r 5 Is F, Cl, CHF 2 Or CF 3 (ii) a Or to pharmaceutically active acid addition salts thereof. The compounds may be used for the treatment of alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis of the dutch type (HCHWA-D), multi-infarct dementia, dementia pugilistica or down syndrome. |
| priorityDate | 2016-10-04^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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