| abstract |
Provided are an FGFR4 inhibitor with the structure of formula (I), a preparation method and application thereof. The series of compounds of formula (I) have a strong inhibitory effect on FGFR4 kinase activity, and have very high selectivity, and can be widely used in the preparation and treatment of cancer, especially liver cancer, gastric cancer, prostate cancer, skin cancer, ovarian cancer, and lung cancer. , breast or colon cancer drugs, is expected to be developed into a new generation of FGFR4 inhibitor drugs. |