http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109758575-B

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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-69
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filingDate 2019-02-14^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2022-08-30^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2022-08-30^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-109758575-B
titleOfInvention Sufficiently diverse amphiphilic MHC II binding polypeptides, immune carrier microspheres, and preparation methods and applications thereof
abstract The present invention relates to sufficiently diverse amphiphilic MHC II binding polypeptides, immune carrier microspheres, and methods for their preparation and use. The sequence structure of the amphiphilic MHC II-binding polypeptide is fatty acyl-β-fold peptide-C-MHC II-binding polypeptide-hydrophilic β-fold peptide-maleimide, and the amphiphilic MHC II-binding polypeptide forms immune carrier microspheres through self-assembly. The coupling groups are located on the surface of the microspheres. It is especially suitable for preparing antibody vaccine for benign disease treatment and preparing antibody vaccine for tumor treatment. The antigen can be coupled to the coupling group on the surface of the immunocarrier microsphere. Antibody vaccines can also be used in combination with FcR‑CART cells or NK cells.
priorityDate 2018-02-14^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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