http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109942673-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2017-12-19^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-12-01^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-12-01^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109942673-B |
| titleOfInvention | GPR1 antagonistic polypeptide, and derivative and application thereof |
| abstract | The invention discloses a GPR1 antagonistic polypeptide and a derivative and application thereof, and particularly relates to a sequence SEQ ID No.1-8 and a derivative thereof, wherein the derivative of a binding peptide is a product obtained by carrying out conventional modification on a GPR1 binding peptide amino acid side chain group and an amino end or a carboxyl end of a GPR1 antagonistic polypeptide fragment, or a product obtained by connecting a label for polypeptide or protein detection or purification to a GPR1 antagonistic polypeptide; the binding peptide and its derivatives can bind to GPR1 in vitro, promote cAMP concentration increase by blocking binding of chemerin and GPR1, and inhibit calcium (Ca) caused by chemerin 2+ ) The medicine can be used for inhibiting the proliferation of breast cancer cells, blocking the cell cycle of the breast cancer cells, promoting the apoptosis of the breast cancer cells, providing effective small molecule medicines for treating female reproductive diseases such as breast cancer and the like, and being widely applied in the fields of medicine and biology. |
| priorityDate | 2017-12-19^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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