| abstract |
Embodiments of the present disclosure include methods and compositions for enhancing the expansion of immune cells for use in immunotherapy. In specific embodiments, immune cells (eg, T cells) express constitutively active cytokine receptors in which the transmembrane and intracellular domains are capable of providing input, respectively, from any input to the corresponding extracellular domains to which they are operably linked. activation signal. In specific embodiments, the transmembrane and intracellular domains from IL-7Rα are used together with the extracellular domain of CD34. |