http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110054574-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C269-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C269-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-22 |
| filingDate | 2019-04-11^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-08-20^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-08-20^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110054574-B |
| titleOfInvention | Synthesis method of fluorenylmethyloxycarbonyl-2, 3-dehydro-valine |
| abstract | The invention relates to a method for synthesizing fluorenylmethyloxycarbonyl-2, 3-dehydro-valine. Mainly solves the technical problem of lack of an effective synthesis method. The synthesis method comprises the following steps: carrying out HWE reaction on Boc-alpha-phosphonoglycine trimethyl ester and acetone in a dichloromethane solution under the catalysis of DBU to generate a compound 1; heating compound 1 and sodium hydroxide in a mixed solution of methanol and water for hydrolysis to generate compound 2; removing a protecting group from the compound 2 in dichloromethane solution of trifluoroacetic acid to generate a compound 3; the compound 3, 9-fluorenylmethyl-N-succinimidyl carbonate and sodium bicarbonate react in a mixed solution of tetrahydrofuran and water to generate a target compound 4. The fluorenylmethyloxycarbonyl-2, 3-dehydro-valine serving as an amino acid derivative is mainly used as a medical intermediate, the synthesis of polypeptide and the like. |
| priorityDate | 2019-04-11^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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