http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110128421-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2018-02-09^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-08-11^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-08-11^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110128421-B |
| titleOfInvention | A kind of simple preparation method of 5-halogenated-7-azaindole |
| abstract | The invention discloses a convenient preparation method of 5-halogenated-7-azaindole. The method utilizes 4,4-dialkoxy-n-butyronitrile (II) and 2,3-dihalogenated acrolein ( III) In the presence of a solvent and a catalyst, 2,3-dihalogenated-4-cyano-6,6-dialkoxy-n-hexanal (IV) is generated through 1,4-addition reaction, and then in alkali, ammonia , ammonium salt, 5-halogenated-7-azaindole (I) is prepared through cyclization reaction. The raw materials used in the invention are cheap and easy to obtain, the process route is short, and the discharge amount of waste water is small, which is beneficial to environmental protection. The reaction operation is convenient, the reaction selectivity is high, the obtained product is high in purity, the yield is high, and the cost is low, and the green industrial production of 5-halogenated-7-azaindole is favorable. |
| priorityDate | 2018-02-09^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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