http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110156681-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_62babfeda07396c6e81938fc957128e8 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-584 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-48 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-48 |
| filingDate | 2019-05-30^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ba9a1931fe23749455ef9aa2036c758 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7e794851e4c96bf43b4ae93f9e62417 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_863f44f2079d3e5e2cb29ddbb18f7e12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f648856e2f62651caad2516f9251d88 |
| publicationDate | 2019-08-23^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-110156681-A |
| titleOfInvention | A kind of synthetic method of 2-ester quinoline |
| abstract | The invention provides a method for synthesizing 2-ester quinoline. Aniline or substituted aniline, phenylacetylene or substituted phenylacetylene and montmorillonite KSF are mixed, and chlorobenzene is used as a solvent for heating reaction; then acetoacetic acid is added The ester and manganese acetate dihydrate catalyst are heated and reacted; after the reaction is completed, after filtration, the filtrate is extracted, dried, filtered and concentrated, and separated by silica gel column chromatography to finally obtain 2-ester quinoline. Compared with the prior art, the raw materials of the present invention are conventional cheap and easily available raw materials; the two-step reaction is carried out in one pot, no intermediate product separation is required, and the efficiency is high; the catalyst montmorillonite and manganese acetate dihydrate are both inexpensive, Safe and non-toxic reagents; mild reaction conditions, high selectivity, few side reactions, simple operations such as separation and purification, and do not involve special operations such as anhydrous and oxygen-free high temperature and high pressure. The separation and purification of the product is simple and the yield is high. From the perspective of reaction mechanism, this is a novel reaction route for the synthesis of 2-ester quinolines. |
| priorityDate | 2019-05-30^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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