| abstract |
The invention provides an acyl-substituted oxazine quinazoline compound, a preparation method and application thereof, and particularly relates to a compound shown in a formula (I), an isomer, a hydrate, a solvate, a pharmaceutically acceptable salt and a prodrug thereof, a preparation method and application thereof in preparation of a drug serving as a kinase inhibitor. The compounds of the invention have good inhibitory activity against mutant EGFR kinase and simultaneously show moderate inhibitory activity against wild-type EGFR kinase. |