| abstract |
The purpose of this invention is to provide a kind of efficient preparation method of (9E,11Z)-9,11-hexadecadienal. The present invention provides a method for preparing (9E, 11Z)-9,11-hexadecadienal (4), the method comprising at least the following steps: after being derived from (8E, 10Z)-1-halogenated-8, A nucleophilic substitution reaction is carried out between (8E, 10Z)-8,10-pentadecadienyl magnesium halide of 10-pentadecanadiene (1) and orthoformate (2), thereby preparing (9E, 11Z)-1,1-dialkoxy-9,11-hexadecadiene (3); and hydrolysis of the (9E,11Z)-1,1-dialkoxy-9,11-hexadecane carbadiene (3) to give (9E,11Z)-9,11-hexadecadienal (4). |