http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111247160-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3d7e2f8fb5650d7d3616661464b67771 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-0094 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J51-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J9-005 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J9-00 |
| filingDate | 2018-11-01^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eeb1bef21626a7e7a93fbbf86de0b253 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80bb42a41b434cfdbb2b28a454a06257 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f96748adfa511ea43f81bdb976019afe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8370ddd1a63b1f7e45e2870eb8fa71b7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb6b3f5b0169f0ea2a84cddfe337170e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c5c634975ef17b315f112e57b39dae8 |
| publicationDate | 2020-06-05^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111247160-A |
| titleOfInvention | A kind of preparation method of cholic acid compound |
| abstract | The application belongs to the field of medicinal chemistry, and relates to a preparation method of a bile acid compound. Specifically, the present application provides a method for preparing a compound represented by formula I, which comprises oxidizing the compound of formula 2 to obtain a compound of formula 3, and the compound of formula 3 is connected to a trimethylsilyl group to obtain a compound of formula 4, and the compound of formula 4 The compound of formula 5 is obtained by reacting with acetaldehyde, the compound of formula 5 is subjected to catalytic hydrogenation reaction to obtain the compound of formula 6, and the cyano group of the compound of formula 6 is converted into a carboxyl group to obtain the compound of formula I. The preparation method has high yield, requires few purification operations, and is suitable for industrial application. |
| priorityDate | 2017-11-02^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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