| abstract |
The present disclosure relates to a kind of immune active peptide-biliverdin conjugate, its preparation method and application in cancer diagnosis, and/or tumor immunotherapy, and/or tumor "photothermal immunotherapy" (tumor photothermal therapy and combined immunotherapy)) The use of (1). The conjugate disclosed by the disclosure can stimulate an organism to generate a tumor immune effect, and can relieve and/or eliminate tumor inflammation, remold a tumor inflammatory microenvironment and realize photo-thermal immune cancer diagnosis and treatment. The conjugate has high biocompatibility, good stability and prolonged half-life, is prepared by chemically synthesizing immune active peptide and biliverdin, has a peptide end with an immune regulation function, and a pigment end with functions of tumor imaging diagnosis, tumor photothermal ablation, immunoinflammatory microenvironment regulation and the like, can obviously enhance an anti-tumor effect, and effectively inhibits tumor metastasis and recurrence. |