http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111943876-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-05 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0482 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F13-005 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K103-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C319-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-41 |
| filingDate | 2020-09-08^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-04-19^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-04-19^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-111943876-B |
| titleOfInvention | A kind of N2S2 bromobenzyl ether derivative, preparation method and application |
| abstract | The invention discloses an N2S2 bromobenzyl ether derivative, a preparation method and an application. The N2S2 bromobenzyl ether derivative is used as a ligand and a complex 99mTc -N2S2-CBMBC formed by labeling with 99mTc can be used as a significant The imaging agent is used in the detection of PD-L1 expression, realizing real-time, comprehensive and convenient detection of PD-L1 level in tumors, overcoming the shortcomings of immunohistochemical methods. According to the N2S2 bromobenzyl ether derivatives, preparation method and application provided by the invention, the labeling rate of the prepared 99m Tc-N2S2-CBMBC is above 94%, and after being placed at room temperature for 6 hours, the radiochemical purity still remains above 90%, It has good stability in vitro at room temperature and is suitable for clinical applications. The lipid-water partition coefficient is 0.91, which can reflect the distribution of drugs between the water and lipid phases in vivo. It has strong cellular uptake ability and high PD-L1 expression. |
| priorityDate | 2020-09-08^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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