| abstract |
The present invention relates to antisense molecules and methods for modulating polyoma T antigen pre-mRNA splicing. In one aspect, the invention relates to an antisense oligonucleotide of 12 to 30, preferably 17, 18, 19 or 20 to 30 nucleobases in length, comprising a sequence that is a polyoma virus T antigen A contiguously extending reverse complement of at least 12 nucleobases of the pre-mRNA, and the antisense oligonucleotide can modulate the splicing of the large T-antigen pre-mRNA in the cell. |