| abstract |
The invention discloses a chiral azaspiroene salt compound and a preparation method thereof. The present invention provides a preparation method of compound 1, comprising the following steps: in a solvent, in the presence of a rhodium catalyst, an oxidant and a chiral acid, the compound shown in formula II and the compound shown in formula III are reacted, Compound 1 is obtained, wherein the compound 1 is a chiral azaspiroene salt compound represented by formula I or a chiral azaspiroene salt compound represented by formula I'. The method can synthesize chiral azaspiroene salt compounds in one step, has excellent yield and enantioselectivity, and has good substrate universality. |