http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112717140-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0075 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 |
| filingDate | 2021-01-18^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-10-18^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-10-18^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-112717140-B |
| titleOfInvention | Preparation and application of a HP1γ-containing guanidylated polyaminoamine polymer gene carrier complex |
| abstract | The invention relates to the technical field of new formulations of biological preparations and gene carriers, in particular to a HP1γ-containing guanidylated polyaminoamine polymer gene carrier complex with euchromatin targeting function and a preparation method and application thereof. The complex is characterized by a guanidylated polyaminoamine base carrier containing target proteins and disulfide bonds, which has good membrane permeability and reduction sensitivity in the intracellular environment, and has an euchromatin targeting effect. In addition to retaining the disulfide bond of the main chain of the original carrier, the guanidylated polyaminoamine polymer AGM-CBA constructed in the present invention is more important for the guanidylation of the main chain, so that this type of carrier has a better membrane permeability and low toxicity. The introduced heterochromatin protein γ can specifically locate in the euchromatin region and upregulate the expression of genes. Its euchromatin targeting can mediate the localization of gene fragments in the transcriptionally active region, and can further promote gene expression through transcription elongation. , to improve the transfection efficiency of the vector complexes. |
| priorityDate | 2021-01-18^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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