| abstract |
An object of the present disclosure is to provide an anti-CD137 antigen binding molecule having immune cell activating effect, cytotoxic activity or anti-tumor activity while hardly affecting non-tumor tissue such as normal tissue and having fewer side effects and a method of using the same. By discovering and preparing CD137 antigen-binding molecules that show changes in CD137-binding activity depending on various substances (eg, low-molecular-weight compounds) in the target tissue and preparing the molecules, it is possible to provide an immune cell activating effect, a cytotoxic activity, or an anti-tumor effect. Anti-CD137 antigen-binding molecule that is active while hardly affecting non-tumor tissues such as normal tissues and has fewer side effects. Also provided are methods of using anti-CD137 antigen binding molecules, pharmaceutical formulations, and the like. The present disclosure also provides an antigen-binding molecule that exhibits altered antigen-binding activity depending on a low-molecular-weight compound, a method for preparing the molecule, and a use of the molecule. |