http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113461660-B

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classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D251-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D251-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14
filingDate 2021-06-11^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2022-08-02^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2022-08-02^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-113461660-B
titleOfInvention 2,4,6-Trisubstituted-1,3,5-s-triazine compounds and their preparation and application
abstract The present invention provides 2,4,6-tri-substituted-1,3,5-s-triazine compounds, preparation and application. Using biguanide or dimethyl biguanide hydrochloride as starting material, under alkaline conditions, react with cyanogen The base compound is prepared by reaction. The present invention provides a simple and convenient method for synthesizing 2,4,6-trisubstituted-1,3,5-s-triazine compounds, and the compounds provided by the present invention can be used in the preparation of anti-myeloid leukemia drug Ensidipine. application. Compared with the prior art, the method for preparing ensidipine of the present invention reduces two-step reactions, avoids the use of halogenated reagents, and is a green and environment-friendly chemical process. Structural formula I is shown below:
priorityDate 2021-06-11^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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