http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113754734-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eac2f8eff077c4682236f6b66083d39a |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 |
| filingDate | 2021-09-30^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa961920b2adddcf18d5d1faa13b8126 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ede5924a65790bc785a1854c9a5635c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba55ec2c80ab0e516747595f61acd650 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9f704e5fd2e927cab23dbc71506a87e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_62d484c4c16b4155a2ed191441c94a13 |
| publicationDate | 2021-12-07^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-113754734-A |
| titleOfInvention | Synthesis method of linaclotide |
| abstract | The invention relates to the technical field of polypeptide synthesis, in particular to a method for synthesizing linaclotide. According to the method, the linaclotide is synthesized by using a specific cracking solution and a two-step cracking method, the first step of cracking is to crack the fully-protected linaclotide from linaclotide fully-protected resin, and an environment-friendly precipitation separation mode is developed, so that the purity of the fully-protected peptide is improved, and the purity of the obtained fully-protected peptide is 91-95%; in the second step, the protecting group of the amino acid side chain is removed by cracking, and the purity of the obtained linear peptide is between 90 and 95 percent. The method greatly improves the purity of linaclotide linear peptide and linaclotide, does not use EDT with high toxicity in the synthesis process, reduces the use of dangerous solvent TFA, has small material dosage and short production period, greatly saves material and time cost, and improves the safety factor of production. |
| priorityDate | 2021-09-30^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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