http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113979930-A
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d09f226784008cd5c44ff11d4dd5b6c3 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-69 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-69 |
filingDate | 2021-11-03^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24dc5ec1a133799f94e22d99d2dfe45d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b02416af42beb905502e063a3245af0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7890b5a316a0ff4b0cb12b32f748914e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da81b39408a7448727b840db091dd316 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d853311c802bd34aa0a45f84defd9130 |
publicationDate | 2022-01-28^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-113979930-A |
titleOfInvention | One-pot method for preparing 2-chloromethyl-3,4-dimethoxypyridine hydrochloride |
abstract | The invention discloses a one-pot method for preparing 2-chloromethyl-3,4-dimethoxypyridine hydrochloride. A certain amount of methyl maltol is added to a pre-configured 10% liquid caustic soda and stirred. Dissolve, drip a certain amount of dimethyl sulfate into it at 10~15 ℃, control the pH value of the reaction solution to be about 9, after the dimethyl ester is added dropwise, be warmed up to 40~45 ℃ and be incubated for 3 hours, cooled to 20 Below ℃, adding dichloromethane for extraction, and concentrating dichloromethane to dryness to obtain compound 2 of higher purity, which can be directly used in the next reaction. The present invention improves the operation method in the original process to obtain 2-chloromethyl-3,4-dimethoxypyridine hydrochloride in a "one-pot method", which not only greatly improves the reaction efficiency, but also avoids intermediates. It simplifies the operation steps and reduces the cost. The one-pot process is simple and reliable, and is beneficial to commercial production and the total yield of the reaction can be up to 60% or more. |
priorityDate | 2021-11-03^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
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