http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114426504-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f4e2a599b8e0355a7caa19905fdab06b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-14 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C269-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C269-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-24 |
| filingDate | 2022-01-27^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08ce4b0e022cd03f0727a7e0a9755b0d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54f54ddd15a789f565f3f1d468285c26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d45d04193d39d8b66a610f04f687b5e1 |
| publicationDate | 2022-05-03^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114426504-A |
| titleOfInvention | A kind of preparation method of trans-(N-4-Boc-aminocyclohexane)acetic acid |
| abstract | The invention discloses a preparation method of trans-(N-4-Boc-aminocyclohexane)acetic acid, and belongs to the technical field of organic synthesis. The specific steps are as follows: the carboxyl group of trans-4-Boc-aminocyclohexanecarboxylic acid is reduced to obtain trans-(N-Boc-4-aminocyclohexyl)methanol, followed by carbon tetrabromide and triphenylphosphine in The reaction is carried out in dichloromethane solution to obtain trans-(N-4-Boc-aminocyclohexane)ethyl bromide, and then the Grignard reagent is exchanged and carbon dioxide is introduced to obtain trans-(N-4-Boc-aminocyclohexane)acetic acid . The raw materials used in the invention are cheap and easy to obtain, have high yield, avoid large-scale toxic cyanide, reduce steps, are suitable for large-scale production, avoid the use of p-toluenesulfonate with genotoxicity, and can be widely used in the field of pharmacy . |
| priorityDate | 2022-01-27^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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