http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114539227-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4daec6f44744e03ef950d85c13746c1a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-10 |
| filingDate | 2021-09-30^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_937f125deea96d0d9febb01f9a6e65d2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3494067e43285adf42ea7eb1a631c88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85149c140fbef2d99e492f4f2b0ec3c3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71b99cd364b0f69dc767672b52bbc28e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_526721b537ff088012f0bb3a6578c8bd |
| publicationDate | 2022-05-27^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114539227-A |
| titleOfInvention | A kind of preparation method of losartan |
| abstract | The invention relates to a method for preparing losartan. In the post-treatment process of the invention, excess sodium azide is dissolved in an aqueous layer and can be removed in a liquid separation process, and a small amount of residual sodium azide can be stored in a water layer. The organic layer is washed and removed by an aqueous sodium chloride solution, so the sodium azide is removed before adding acid for crystallization, so as to avoid the generation of highly toxic and polluting azide acid that is harmful to people and the environment during the acid dripping process, and also reduces the The generation of azide-based poisonous impurities under acidic crystallization conditions; the aqueous layer containing sodium azide is separated and collected and treated with sodium nitrite to avoid the contact between the organic layer of losartan product and sodium nitrite to produce nitrosamines Impurities, the impurity test results of losartan conform to national standards and guidelines; the organic solvents used in the entire process are dichloromethane and toluene, which can be recycled and reused, reducing process costs, and being environmentally friendly; the entire process is simple and easy to operate. Suitable for industrial production. |
| priorityDate | 2021-09-30^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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