| abstract |
The present invention provides a substituted condensed tricyclic derivative, a composition comprising the compound and use thereof, wherein the substituted condensed tricyclic derivative is a compound represented by formula (I) or its tautomerism isomers, stereoisomers, prodrugs, crystal forms, pharmaceutically acceptable salts, hydrates or solvates. The compounds and compositions of the present invention are useful in the treatment and/or prevention of mutated EGFR kinase-mediated tumors, as well as wild-type and/or mutated HER2 kinase-mediated tumors. |