http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115201465-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_979a903bb5321c73816eb7c0e822abcb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-54306 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-543 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate | 2021-04-08^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e649c340b24e5e469ca2ac5703e830c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_266a092231ae6463aec2a4667071962e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ec96632922b4d38328d4428c2977795 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56af399ca9f5136923ad006ac2b1c5de http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ea1251e239bce2cc151a50edcfe020a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_62b4398920f95ca635acddc9c11be37a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09f5eb3db270c80db49494c5f5a89d14 |
| publicationDate | 2022-10-18^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-115201465-A |
| titleOfInvention | Screening method of polypeptides specifically bound by antibodies based on polypeptide chip and application of the screened polypeptides |
| abstract | The present invention provides a method for screening polypeptides specifically bound by an antibody based on a polypeptide chip and the application of the screened polypeptides. The screening method includes using a peptide chip to screen antibody-containing sample dilutions and antibody-free sample dilutions for the first time under blocking and non-blocking conditions, respectively, to obtain the first seed peptide library under blocking conditions and non-blocking conditions. The first seed peptide library under the two conditions; the second seed peptide library is obtained by taking the intersection of the polypeptides in the first seed peptide library under the two conditions; the serum samples containing antibodies and the antibodies without antibodies were analyzed using a peptide chip under blocking conditions. The serum sample is screened for the second time to obtain the third seed peptide library; the intersection of the third seed peptide library and the second seed peptide library is taken to obtain the fourth seed peptide library; the antibody is one or more single antibodies, or multiple mixed antibodies . The method excludes interfering peptides under different conditions, and the obtained peptide collection has higher specificity, which is suitable for the detection of antibodies in complex clinical samples. |
| priorityDate | 2021-04-08^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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