http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115413295-A

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publicationDate 2022-11-29^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-115413295-A
titleOfInvention Systems for Electroporation of Particles
abstract Systems for cell bioprocessing and cell therapy manufacturing can include a series of microfluidic modules to enable continuous flow end-to-end cell bioprocessing. Each module can implement a different technology, and the modules can be coupled to each other to perform various unit operations in the cell bioprocessing or cell therapy manufacturing chain, enabling direct processing of blood or blood product samples. The system can automatically and continuously process samples into genetically modified lymphocytes or T cells for cell therapy. The techniques implemented by each module in the system can include any combination of microfluidic acoustophoresis, microfluidic acoustophoresis medium exchange or cell washing, and continuous flow microfluidic electrotransfection. The modules implementing these microfluidics can be interconnected with plastic tubes or custom manifolds.
priorityDate 2019-11-22^^<http://www.w3.org/2001/XMLSchema#date>
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