http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CO-5550423-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bb66d9373d09efad73c142762f6dfb00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D451-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D451-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 |
| filingDate | 2004-01-20^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e64c620a79a743ddbdcc54f1f7c62edb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3df2541c2a1043efe71eee86d88181c9 |
| publicationDate | 2005-08-31^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CO-5550423-A2 |
| titleOfInvention | CRYSTAL ANTI-POLINERGIC AGENT, PROCEDURE FOR PREPARATION AND USE FOR THE PREPARATION OF A MEDICINAL PRODUCT |
| abstract | 1.- Anhydrous crystalline tiotropium bromide, characterized by a monoclinic elementary cell determined by structural X-ray analysis with the parameters a = 10.4336 (2) Å, b = 11.3297 (3) Å, c = 17.6332 (4) Å ya = 90 °, ß = 105,158 (2) ° and Y = 90 ° (cell volume = 2011,89 (8) Å 3) .2.- Procedure for the preparation of crystalline anhydrous tiotropium bromide according to claim 1, characterized in that it is prepared by careful drying at more than 50 ° C, preferably at 60-100 ° C, under reduced pressure. 3.- Method according to claim 2, characterized in that the drying takes place over a period of time. from 15 minutes to 24 hours. 4. Process for the preparation of crystalline anhydrous tiotropium bromide according to claim 1, characterized in that it is prepared by storage of crystalline tiotropium bromide monohydrate on an appropriate drying agent during a period of drying. time from 12 to 96 h oras. 5.- Crystalline anhydrous tiotropium bromide, obtainable according to one of claims 2, 3 or 4.6.- Use of crystalline tiotropium bromide monohydrate for the preparation of crystalline anhydrous tiotropium bromide. 7.- Medication characterized by a certain content of crystalline tiotropium bromide according to one of claims 1 or 5.8.- Medication according to claim 7, characterized in that it is an inhalable powder. 9.- Inhalable powder according to claim 8, characterized in that it contains crystalline anhydrous tiotropium bromide of according to claim 1 or 5 in admixture with a physiologically tolerable auxiliary substance.10.- Inhalable powder according to claim 9, characterized in that the auxiliary substance is chosen from the group consisting of glucose and lactose. |
| priorityDate | 2001-06-22^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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