| abstract |
A compound of the formula I in free or salt or solvate form, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 have the meanings indicated in the specification, is useful for the treatment of diseases that respond to the blockage of the epithelial sodium channel. Also described are pharmaceutical compositions containing the compounds, and processes for the preparation of the compounds. Diseases that respond to blockade of the epithelial sodium channel (ENaC) are inflammatory or allergic conditions selected from: cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, pulmonary carcinoma, xerostomia and keratoconjunctivitis . |