| abstract |
The present invention relates, inter alia, to compounds having the general formula (I) in which: R1 is a member selected from the group consisting of -OCH3, -SCH3, -N (CH3) 2, -NHCH3, -NC4H8 , -NC5H10, -NC4H8O, -CHO, -CH (OH) CH3, -C (O) CH3, -O (CH2) 2N (CH3) 2 and -O (CH2) 2NC5H10 - R2 is a member selected from a group consisting of hydrogen, halogen, alkyl, acyl, hydroxyl, alkyl (e.g. methoxy, ethoxy, vinyloxy, ethynyloxy, cyclopropyloxy, etc.), acyloxy (e.g. acetoxy, glycinate, etc.) alkylcarbonate, zypionyloxy, S-alkyl, -SCN, S-acyl and -OC (O) R6, wherein t R6 is a moiety including, but not limited to, alkyl (e.g. methyl, ethyl, etc.), alkoxy (e.g. -CH2OCH3) and alkoxy (-OCH3) - R3 is a member selected from the group consisting of alkyl, hydroxyl, alkoxy and acyloxy; R4 is a member selected from the group consisting of hydrogen and alkyl; and X is a member selected from the group consisting of = O and = N- OR5, wherein R5 is a member selected from the group consisting of hydrogen and alkyl. In addition to providing the compounds of Formula I, the present invention provides methods in which the compounds of Formula I are advantageously used, inter alia for antagonizing endogenous progesterone; for inducing menstruation- for the treatment of endometriosis- for the treatment of dysmenorrhea- for endocrine-dependent tumor hormone treatment - for the treatment of meningiomas - for the treatment of uterine leiomyomas - for the treatment of uterine fibroids - for the treatment of endometrial proliferation - for the induction of tracheal maturation Lou the uterus for inducing birth of a child and for contraception. |