| abstract |
The invention relates to a process for trifluoromethoxylation. In order to provide a novel trifluoro-methoxylation, it is proposed in the invention that a combination of 2,2-difluoro-1,3-dimethylimidazoline and trifluoromethyl triflate with alcohols of the formula is implemented, where R 1 = H, Cl, Br, I, CN, COOR 4, alkyl, allyl, propargyl, aryl, heteroaryl, cycloalkyl R 2 = H, Cl, Br, I, CN, COOR 4, alkyl, allyl, propargyl, aryl, heteroaryl, cycloalkyl R 3 = H, Cl, Br, I, CN, COOR4, alkyl, allyl, propargyl, aryl, heteroaryl, cycloalkyl. The process is a one-pot process for the preparation of trifluoromethoxylated compounds in which functionalized alcohols are reacted directly to the corresponding trifluoromethyl ether derivatives. The main advantages of this process are the high conversion rates despite the low nucleophilicity of the trifluoromethoxy anion, the chemoselectivity, the mild reaction conditions and the ease of conversion. |