| abstract |
Pharmaceutical compsn. for topical application for treating virus diseases of the skin and mucous membranes contains (a) a virustatic cpd. of the antimetabolite type, and (b) an Ag, Bi, Cu or Zn salt, in a conventional carrier plus usual additives. The compsn. is esp. formulated as a gel and the pref. active ingredients are ZnSO4 and beta-5-ethyl-2'-deoxyuridine. Used partic. for treating herpes infections. The metal salts are effective against RNA and DNA viruses; do not induce development of resistant strains; are not teratogenic or mutagenic and do not delay regeneration of affected tissue. They also intensify and extend the activity of (I) allowing smaller doses to be used. |