| abstract |
Previously unknown trifluoromethanesulphonates having the general formula <IMAGE> in which R<1> denotes hydrogen or (C2-6)-alkyl which can optionally be substituted by amino, (C1-6)-acylamino or benzoylamino, (C2-6)-alkenyl, (C3-9)-cycloalkyl, (C5-9)- cycloalkenyl, (C3-7)-cycloalkyl-(C1-4)-alkyl, (C6-12)- aryl or partially hydrogenated aryl which can always be substituted by (C1-4)-alkyl, (C1 or 2)-alkoxy or halogen, (C6-12)-aryl-(C2-4)-alkyl or (C7-13)-aroyl-(C1-2)-alkyl, both of which can be substituted in the aryl moiety as described above, a monocyclic or bicyclic heterocyclic radical having 5-7 or 8-10 ring atoms of which 1-2 ring atoms are sulphur or oxygen atoms, and/or 1-4 ring atoms are nitrogen, or a side chain from a naturally occurring protected α-amino acid, and R<3> denotes hydrogen, (C1-6)-alkyl, (C2-6)-alkenyl or (C6-12)-aryl-(C1-4)-alkyl or (C6-12)-aryl-(C1-4)-alkyl, can be prepared by reacting α-hydroxycarboxylic acid derivatives of the formula <IMAGE> in which R<1> and R<3> have the abovementioned meanings, with a trifluoromethanesulphonating agent, where appropriate in the presence of a base. The compounds (III) can be used as starting compounds for preparing known compounds which have an inhibitory effect on the angiotensin converting enzyme (ACE) and can be used for controlling elevated blood pressure. |