| abstract |
The invention provides compounds of formula (I) wherein R 1 is a fluorine or chlorine atom; R represents a hydrogen atom; R 1 is methyl; R 1 is ethyl, isopropyl, methoxy, difluoromethoxy or cyclopropyl; R represents a hydrogen atom; X represents —CH—; Y represents a hydrogen atom and Y represents methoxy; ethylsulfonylamino; acetyl; tert-butylcarbonyl; isopropylcarbonyl; pyrazolyl optionally substituted with one radical selected from chloro, isopropyl and cyclopropyl; oxazol-2-yl optionally substituted with cyclopropyl; imidazolyl optionally substituted with methyl or isopropyl; thiazol-2-yl; pyrimid-2-yl or 5-cyclopropylisoxazol-2-yl; which are CRTH2 ligands useful in the treatment of, for example, asthma and COPD. |