| abstract |
The invention relates to new compounds of the formula (I), their stereoisomers or their pharmaceutically acceptable salts where X, X, Chi are independently selected from CR and N; with the proviso that at least one and not more than two of X, X, Xi Xob are N; Y is a substituted amino group or a substituted or unsubstituted C-C-cycloalkyl, heterocycloalkyl or heteroaryl; Z, Z and Z are independently selected from CR and N; provided that no more than one of Z, Z and Z may be N; R and R have the meanings indicated in the description; pharmaceutical compositions for the treatment of cancer containing the compounds, a method of inhibiting kinase activity associated with oncogenesis in humans or animals, and the use of new compounds individually or in combination with at least one additional therapeutic agent for the prevention or treatment of cancer. |