| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dbdae384a9f1ad0588422c89ddc71a00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7dfb0281008cb570feea037cd350c8f |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-065
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-06 |
| filingDate |
2012-08-27^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b449651d9082901d975cc6616b093980
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41112df09de6a663b59385d434ba7024
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_abbcc57502cde204300af4193056f2c5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9fc3ebf58cb31d2db120c2e3ca58a86f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d4564793647c98102bddec2943f84f0 |
| publicationDate |
2018-07-31^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EA-030251-B1 |
| titleOfInvention |
METHOD OF REDUCING THE THROMBOEMBOLIC POTENTIAL OF THE COMPOSITION CONTAINING IMMUNOGLOBULIN RECEIVED FROM PLASMA |
| abstract |
The invention provides methods for reducing the content of amidolytic activity and activity against complement (APC) in a composition containing an immunoglobulin by using cation-exchange chromatography. In a specific embodiment of the invention, methods are provided for reducing the content of factor XI and / or factor XIa and / or APC in a composition comprising an immunoglobulin by collecting an early fraction of the eluate of a cation-exchange column. The invention also provides a composition comprising an immunoglobulin that contains reduced levels of amidolytic activity, factor XI and / or factor XIa and / or APC. |
| priorityDate |
2011-08-26^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |