| abstract |
The claimed compounds, methods of use and methods for producing complement factor D inhibitors, including formula I, or a pharmaceutically acceptable salt thereof, or a composition thereof, wherein R or R on group A is aryl, heteroaryl or heterocycle (R). The inhibitors described herein act on factor D and inhibit or regulate the complement cascade at an early and significant point in the alternative complement pathway and reduce the ability of factor D to modulate the classic and lectin complement pathways. The factor D inhibitors described herein are capable of reducing excessive complement activation, which is associated with certain autoimmune, inflammatory, and neurodegenerative diseases, as well as ischemic reperfusion injury and cancer. |