| abstract |
Basic esters of 1,4-dihydropyridine-3,5-dicarboxylic acid of formula (I)are described, in which R' is a linear or branched alkyl radical containing 1-5 carbon atoms which is unsubstituted or substituted by an alkoxy group; R<sup>2</sup> is a phenyl or a nitrophenyl radical; R<sup>3</sup> is phenyl, phenyl substituted by one to three radicals selected from (C<sub>1-4</sub>)alkyl, (C<sub>1-4</sub>)alkoxy, fluoro, chloro, bromo, nitro, cyano, carb(C<sub>1-4</sub>)alkoxy, trifluoromethyl, hydroxy, amino, mono- or di-alkylamino, mono- or di-acylamino, mercapto, S(O)<sub>n</sub>-alkyl with n = 0,1 or 2, (C<sub>1</sub>-C<sub>5</sub>)acyl, carbamoyl, ureido or R<sup>3</sup> is a 5 or 6 membered heteroaryl monocyclic radical which contains one or more heteroatoms which are N, 0 or S such as unsubstituted pyridyl, pirazinyl, pyrimidyl, furyl, imidazolyl, thienyl, thiazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl or mono-, di- or tri-substituted with alkyl, alkoxy, halogen or trifluoromethyl; X is a linear or branched alkylen radical containing between 2 and 5 carbon atems which is unsubstituted or substituted by an alkoxy group and their racemates, enantiomers and diastereoisomers and addition salts thereof with a pharmaceutically acceptable acid. The novel compounds exhibit calcium antagonistic activity. |