http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0126094-B1

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filingDate 1983-11-18^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1990-06-20^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1990-06-20^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0126094-B1
titleOfInvention New 1,4-dihydropyridine esters and preparation methods thereof and drugs containing said esters
abstract 1,4-dihydropyridine esters (and their salts), having the formula (I), wherein R is a hydrogen atom, a saturated or unsaturated hydrocarbonated rest, or an alkylmorpholinic group, R2 and R3 represent a hydrogen atom or an alkyl group, n is 0, 1, 2 or 3, X is an aryl rest, a benzyl, styryl, cycloalkyl, cycloalkenyl group or a naphtyl, quinolyl, isoquinolyl, pyridyl, pyrimidyl, diphenyl, furyl, pyrryl or thiophenyl rest which is optionally substituted. R1 is a straight or branched chain, saturated, unsaturated or cyclic hydrocarbonated rest which may be interrupted by one or two oxygen or sulphur atoms and which may also be substituted by one or two hydroxyl groups. R1 may also represent the group formula (II); Y represents: a) the N-substituted amides of the nicotinic, salicylic and 4-hydroxybenzoic acids or of the monoalkylated, monoacylated or sulfonylated N-substituted piperazines having the formula: $(4,)$ b) a group having the formula: -OOC-R6 and -O-R6, wherein R6 is a saturated, unsaturated or cyclic, branched or not, heterocyclic or aromatic hydrocarbonated rest, which may optionally be substituted, c) the 2-tetrahydrofluryl and N-(4-benzoylpyperidinyl) rests. The 1, 4-dihydropyridine esters (and their salts) are prepared to be used as pharmacologically active ingredients, particularly in drugs intended to the preventive and curative treatment or cardiovascular troubles.
priorityDate 1982-11-24^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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