| abstract |
Novel aroyl-substituted benzofuran and benzothiophene acetic and propionic acids of the formula:n or a pharmaceutically acceptable salt wherein:n R, is hydrogen, hydroxy, C1-6 alkoxy, or methyl; R. is hydrogen or methyl; R 3 is hydrogen, C 1 - 12 alkyl, phenyl, phenyl Ci-6 alkyl, 2-furyl, 3-furyl, 2-thienyl, 3-thienyl,n n wherein the R groups are the same and are C 1-6 alkyl; X, is oxygen or is sulfur if R, is hydrogen; X 2 is oxygen or sulfur; n Ar is phenyl unsubstituted or independently substituted with one or more substituents which are C1-6 alkyl, C1-6 alkoxy, halo, C1-6 alkyl sulfinyl, Ci-6 alkyl sulfonyl, C1-6 alkyl thio, or 2-furyl, 3-furyl, 2-thienyl, or 3-thienyl; and the dotted line represents a single or double bond. n These compounds are useful as analgesic, anti-inflammatory, and antipyretic agents. |