| abstract |
New antibacterial agents are compounds of formula n<CHEM>n wherein R is hydrogen atom or C1-C4 alkyl group optionally substituted from halogen atom or hydroxy group optionally protected, A is Z, ZOCO or ZCO residue, wherein Z is phenylene, naphthylene, heterocyclediyl, C1-C7 alkylene, C2-C4 alkenylene, alkynylene, n<CHEM>n, C3-C8 cycloalkylene, aralkylene radical optionally substituted, and Q<(+)> represents a group n<CHEM>n, wherein R1, R2 and R3 are each either: n n (i) optionally substituted alkyl, aralkyl or aryl radical or n (ii) R1 is as defined above under (i) and R2, R3, taken together, represent an optionally substituted or fused heterocyclic radical or n (iii) R1, R2, R3 taken together, represent an optionally substituted azonia-bicyclo or tricyclo radical or n (iv) R1, R2, R3, taken together, represent an optionally substituted or fused pyridinium, pyrazinium, pyrazolium or pyridazinium radical, and the pharmaceutically or veterinarily acceptable salts thereof. n n<??>The compounds are prepared by reacting the amine NR, R<2> R<3> with the corresponding penem substituted in the s positions by A-HC2-L group where A is as defined above and L is a leaving group. |