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filingDate 1986-06-18^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6576134e7ffa25caa47a8a8a1e0e5f5e
publicationDate 1986-12-30^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0206241-A1
titleOfInvention Process for the preparation of cis-5-fluoro-2-methyl-1-(4-methylthiobenzylidene)-indene-3-acetic acid
abstract A process is described for the preparation of cis-5-fluoro-2-methyl-1-(4-methylthiobenzylidene)-indene-3-acetic acid that consists in reacting a lower alkyl ester of 5-fluoro-2-methyl-indene-3-acetic acid with a substantially equimolecular amount of 4-methylthio-benzaldehyde in a solid-liquid two-phase system in which the solid phase is a potassium alcoholate or hydroxide and the liquid phase is a solution of the reagents in an organic solvent inert under the reaction conditions, in the presence of a phase transfer catalyst and at a temperature comprised between -20 and +20°C.
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